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Aufsatz zugänglich unter
URN: urn:nbn:de:bvb:29-opus-36185
URL: http://www.opus.ub.uni-erlangen.de/opus/volltexte/2012/3618/
Expression of human Piwi-like genes is associated with prognosis for soft tissue sarcoma patients
Greither, Thomas ;
Koser, Franziska ;
Kappler, Matthias ;
Bache, Matthias ;
Lautenschläger, Christine ;
Göbel, Steffen ;
Holzhausen, Hans-Jürgen ;
Wach, Sven ;
Würl, Peter ;
Taubert, Helge
| Originalveröffentlichung: |
| (2012) BMC Cancer 12.272 (2012): 24.10.2012 <http://www.biomedcentral.com/1471-2407/12/272> |
| pdf-Format:
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| SWD-Schlagwörter: |
| - |
| Collection: |
| Universität Erlangen-Nürnberg / Open Access Artikel ohne Förderung / 2012 |
| Fakultät: |
| Medizinische Fakultät |
| DDC-Sachgruppe: |
| Medizin |
| Dokumentart: |
| Aufsatz |
| Sprache: |
| Englisch |
| Erstellungsjahr: |
| 2012 |
| Publikationsdatum: |
| 24.10.2012 |
| Kurzfassung in Englisch: |
| Background
Argonaute genes are essential for RNA interference, stem cell maintenance and differentiation. The Piwi-like genes, a subclass of the Argonaute genes, are expressed mainly in the germline. These genes may be re-expressed in tumors, and expression of the Piwi-like genes is associated with prognosis in several types of tumors.
Methods
We measured the expression of Piwi-like mRNAs (Piwi-like 2–4) in 125 soft tissue sarcoma (STS) samples by qPCRs. Statistical tests were applied to study the correlation of expression levels with tumor-specific survival for STS patients.
Results
In multivariate Cox’s regression analyses, we showed that low Piwi-like 2 and Piwi-like 4 mRNA expression were significantly associated with a worse prognosis (RR = 1.87; p = 0.032 and RR = 1.82; p = 0.039). Low expression of both genes was associated with a 2.58-fold increased risk of tumor-related death (p = 0.01). Piwi-like 4 and combined Piwi-like 2 and 4 mRNA levels correlated significantly with prognosis (RR = 3.53; p = 0.002 and RR = 5.23; p = 0.004) only for female but not for male patients. However, combined low Piwi-like 2 and 3 transcript levels were associated with worse survival (RR = 5.90; p = 0.02) for male patients.
Conclusions
In this study, we identified a significant association between the expression of Piwi-like 2 and 4 mRNAs and the tumor-specific survival of soft tissue sarcoma patients. Furthermore, a connection between sex and the impact of Piwi-like mRNA expressions on STS patients’ prognosis was shown for the first time. |
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