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ResearchPaper zugänglich unter
URN: urn:nbn:de:bvb:29-opus-39200
URL: http://www.opus.ub.uni-erlangen.de/opus/volltexte/2012/3920/
Low magnesium in food is an abettor of calcium and magnesium accumulation in renal tissue, and dyslipidemia? Observations in men with idiopathic recurrent calcium urolithiasis responding to a low magnesium containing test meal with different degree of unrecovered magnesium in urine, and male rats fed a magnesium-deficient diet. With a re-appraisal of stone pathophysiology
Schwille, Paul Otto
| SWD-Schlagwörter: |
| Nahrung , Magnesium , Lipidstoffwechselstörung , Nephrocalcinose |
| Freie Schlagwörter (Deutsch): |
| Niedriges Nahrungsmagnesium , Magnesium Retention , Calcium Urolithiasis beim Menschen , Dyslipidämie, Nephrocalcinosis bei Ratten |
| Freie Schlagwörter (Englisch): |
| Low dietary magnesium, magnesium retention, calcium urolithiasis of humans, dyslipidemia, nephrocalcinosis of rats |
| Fakultät: |
| Medizinische Fakultät |
| DDC-Sachgruppe: |
| Medizin |
| Dokumentart: |
| ResearchPaper |
| Sprache: |
| Englisch |
| Erstellungsjahr: |
| 2012 |
| Publikationsdatum: |
| 29.11.2012 |
| Kurzfassung in Englisch: |
| Background: The role of Mg in pathophysiology of IRCU is incompletely understood and would benefit from animal models. Aims: To elucidate whether 1) Mg nutrition in IRCU impacts on minerals and lipids in blood, minerals in urine, 2) dietary Mg deficiency of rats can serve as model for renal Ca and Mg accumulation. Procedures: 1. Adult male patients (clinical trial 1; n = 88) underwent a standardized laboratory program (urine and blood collections, intake of a TM with low Mg (type 1); from Mg retention, viz. Mg not appearing in urine, and stratification Mg retention ≥50% (H) or <50% (L), Mg nutrition was extrapolated. Clinical trial 2 (27 patients, 16 healthy controls): TM type 2 (suboptimal Mg, normal Ca and Na content) and type 1 were separately ingested. 2. Male Sprague-Dawley rats were fed normal (n = 12) or Mg-deficient (n = 11) diet over 111 days; Mg, Ca, Pi were determined in dry tissues (three kidney regions, artery, bone), urine and blood. Analyses: Established techniques were used. Key findings: In trial 1, mean Mg in 24 h urine of all patients was low relative to recommended Mg intake per day, decreased in subset H (n = 22) vs. L (n = 66) (p = 0.0015); volume, Ca, pH, Na, UA, MDA, Ca salt supersaturation were decreased in postprandial urine of H vs. L; there was dyslipidemia (decrease of HDL-CH, increase of VLDL-CH, TGL, total lipids, Lp(a)) and increase of uricemia. Determinants of Mg retention (multivariate correlations) were urine Ca, volume (negative), serum total CH + TGL (positive), explaining 40% of variation. In trial 2 TM type 2 vs. TM type 1 evoked increase of Mg and Na retention in IRCU (+70% and +30%, resp.), but decrease of Na retention in controls (-45%). Rats fed low Mg diet exhibited hypomagnesemia (total, ionized), hypercholesterolemia, higher mean urine MDA and Pi per unit body weight, increase of Mg in renal medulla, Ca in all kidney regions, decrease of bone Mg, undetectably low Mg in aorta, Conclusions: 1) In IRCU assessment of Mg retention from a meal allows to gauge Mg nutrition, renal contribution to Mg, Ca and Na homeostasis. 2) Mg undernutrition is an effector of dys- and hyperlipidemia (IRCU, rats), renal Ca and Mg accumulation (rats). 3) From present and earlier work in this area a Mg deficit and lipid excess related vascular etiology of IRCU is suggested. |
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