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Aufsatz zugänglich unter
URN: urn:nbn:de:bvb:29-opus-38851
URL: http://www.opus.ub.uni-erlangen.de/opus/volltexte/2012/3885/
Regulation of MMP-9 by a WIN-Binding Site in the Monocyte-Macrophage System Independent from Cannabinoid Receptors
Tauber, Svantje ;
Paulsen, Katrin ;
Wolf, Susanne ;
Synwoldt, Peggy ;
Pahl, Andreas ;
Schneider-Stock, Regine ;
Ullrich, Oliver
| Originalveröffentlichung: |
| (2012) PLoS ONE 7.11 (2012): 15.11.2012 <http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0048272> |
| pdf-Format:
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| SWD-Schlagwörter: |
| - |
| Collection: |
| Universität Erlangen-Nürnberg / Open Access Artikel ohne Förderung / 2012 |
| Fakultät: |
| Medizinische Fakultät |
| DDC-Sachgruppe: |
| Medizin |
| Dokumentart: |
| Aufsatz |
| Sprache: |
| Englisch |
| Erstellungsjahr: |
| 2012 |
| Publikationsdatum: |
| 16.11.2012 |
| Kurzfassung in Englisch: |
| The cannabinoid system is known to be involved in the regulation of inflammatory processes. Therefore, drugs targeting cannabinoid receptors are considered as candidates for anti-inflammatory and tissue protective therapy. We demonstrated that the prototypical cannabinoid agonist R(+)WIN55,212-2 (WIN) reduced the secretion of matrix metalloproteinase-9 (MMP-9) in a murine model of cigarette-smoke induced lung inflammation. In experiments using primary cells and cell lines of the monocyte-macrophage-system we found that binding of the cannabinoid-receptor agonist WIN to a stereo-selective, specific binding site in cells of the monocyte-macrophage-system induced a significant down-regulation of MMP-9 secretion and disturbance of intracellular processing, which subsequently down-regulated MMP-9 mRNA expression via a ERK1/2-phosphorylation-dependent pathway. Surprisingly, the anti-inflammatory effect was independent from classical cannabinoid receptors. Our experiments supposed an involvement of TRPV1, but other yet unidentified sites are also possible. We conclude that cannabinoid-induced control of MMP-9 in the monocyte-macrophage system via a cannabinoid-receptor independent pathway represents a general option for tissue protection during inflammation, such as during lung inflammation and other diseases associated with inflammatory tissue damage. |
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